Article
Positive Allosteric Modulation of Kv Channels by Sevoflurane: Insights into the Structural Basis of Inhaled Anesthetic Action.
PloS one - 1 Jan 2015
Liang Qiansheng, Anderson Warren D, Jones Shelly T, Souza Caio S, Hosoume Juliana M, Treptow Werner, Covarrubias Manuel
Abstract excerpt
Inhalational general anesthesia results from the poorly understood interactions of haloethers with multiple protein targets, which prominently includes ion channels in the nervous system. Previously, we reported that the commonly used inhaled anesthetic sevoflurane potentiates the activity of voltage-gated K+ (Kv) channels, specifically, several mammalian Kv1 channels and the Drosophila K-Shaw2 channel. Also,...
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