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Article

Propofol inhibits prokaryotic voltage-gated Na+ channels by promoting activation-coupled inactivation.

The Journal of general physiology - 3 Sept 2018

Yang Elaine, Granata Daniele, Eckenhoff Roderic G, Carnevale Vincenzo, Covarrubias Manuel

Abstract excerpt

Propofol is widely used in the clinic for the induction and maintenance of general anesthesia. As with most general anesthetics, however, our understanding of its mechanism of action remains incomplete. Local and general anesthetics largely inhibit voltage-gated Na+ channels (Navs) by inducing an apparent stabilization of the inactivated state, associated in some instances with pore block. To determine the...

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Identifiers

PMID: 30018038
DOI: 10.1085/jgp.201711924
PMCID: PMC6122921

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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