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Article

Molecular mapping of general anesthetic sites in a voltage-gated ion channel.

Biophysical journal - 5 Oct 2011

Barber Annika F, Liang Qiansheng, Amaral Cristiano, Treptow Werner, Covarrubias Manuel

Abstract excerpt

Several voltage-gated ion channels are modulated by clinically relevant doses of general anesthetics. However, the structural basis of this modulation is not well understood. Previous work suggested that n-alcohols and inhaled anesthetics stabilize the closed state of the Shaw2 voltage-gated (Kv) channel (K-Shaw2) by directly interacting with a discrete channel site. We hypothesize that the inhibition of K-Shaw2...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 21961587
DOI: 10.1016/j.bpj.2011.08.026
PMCID: PMC3183804

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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