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Article

Voltage-Gated Na+ Channels: Not Just for Conduction.

Cold Spring Harbor perspectives in biology - 1 Jun 2016

Kruger Larisa C, Isom Lori L

Abstract excerpt

Voltage-gated sodium channels (VGSCs), composed of a pore-forming α subunit and up to two associated β subunits, are critical for the initiation of the action potential (AP) in excitable tissues. Building on the monumental discovery and description of sodium current in 1952, intrepid researchers described the voltage-dependent gating mechanism, selectivity of the channel, and general structure of the VGSC...

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Identifiers

PMID: 27252364
DOI: 10.1101/cshperspect.a029264
PMCID: PMC4888818

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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