Article
Structures of closed and open states of a voltage-gated sodium channel.
Proceedings of the National Academy of Sciences of the United States of America - 11 Apr 2017
Lenaeus Michael J, Gamal El-Din Tamer M, Ing Christopher, Ramanadane Karthik, Pomès Régis, Zheng Ning, Catterall William A
Abstract excerpt
Bacterial voltage-gated sodium channels (BacNavs) serve as models of their vertebrate counterparts. BacNavs contain conserved voltage-sensing and pore-forming domains, but they are homotetramers of four identical subunits, rather than pseudotetramers of four homologous domains. Here, we present structures of two NaVAb mutants that capture tightly closed and open states at a resolution of 2.8-3.2 Å. Introduction...
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