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Article

Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications.

Journal of medicinal chemistry - 24 Sept 2015

de Lera Ruiz Manuel, Kraus Richard L

Abstract excerpt

The tremendous therapeutic potential of voltage-gated sodium channels (Na(v)s) has been the subject of many studies in the past and is of intense interest today. Na(v)1.7 channels in particular have received much attention recently because of strong genetic validation of their involvement in nociception. Here we summarize the current status of research in the Na(v) field and present the most relevant recent...

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PMID: 25927480
DOI: 10.1021/jm501981g

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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