Article
Inhalational anaesthetics and n-alcohols share a site of action in the neuronal Shaw2 Kv channel.
British journal of pharmacology - 1 Apr 2010
Bhattacharji Aditya, Klett Nathan, Go Ramon Christopher V, Covarrubias Manuel
Abstract excerpt
BACKGROUND AND PURPOSE: Neuronal ion channels are key targets of general anaesthetics and alcohol, and binding of these drugs to pre-existing and relatively specific sites is thought to alter channel gating. However, the underlying molecular mechanisms of this action are still poorly understood. Here, we investigated the neuronal Shaw2 voltage-gated K(+) (K(v)) channel to ask whether the inhalational anaesthetic...
Topics
- Alcohols
- Anesthetics, Inhalation
- Animals
- Halothane
- Mutation
- Neurons
- Shaw Potassium Channels
- Xenopus laevis