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Article

Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism.

Proceedings of the National Academy of Sciences of the United States of America - 10 Jun 2014

Bagnéris Claire, DeCaen Paul G, Naylor Claire E, Pryde David C, Nobeli Irene, Clapham David E, Wallace B A

Abstract excerpt

Voltage-gated sodium channels are important targets for the development of pharmaceutical drugs, because mutations in different human sodium channel isoforms have causal relationships with a range of neurological and cardiovascular diseases. In this study, functional electrophysiological studies show that the prokaryotic sodium channel from Magnetococcus marinus (NavMs) binds and is inhibited by eukaryotic sodium...

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Identifiers

PMID: 24850863
DOI: 10.1073/pnas.1406855111
PMCID: PMC4060673

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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