Article
Targeting the voltage sensor of Kv7.2 voltage-gated K+ channels with a new gating-modifier.
Proceedings of the National Academy of Sciences of the United States of America - 31 Aug 2010
Peretz Asher, Pell Liat, Gofman Yana, Haitin Yoni, Shamgar Liora, Patrich Eti, Kornilov Polina, Gourgy-Hacohen Orit, Ben-Tal Nir, Attali Bernard
Abstract excerpt
The pore and gate regions of voltage-gated cation channels have been often targeted with drugs acting as channel modulators. In contrast, the voltage-sensing domain (VSD) was practically not exploited for therapeutic purposes, although it is the target of various toxins. We recently designed unique diphenylamine carboxylates that are powerful Kv7.2 voltage-gated K(+) channel openers or blockers. Here we show that...
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