Article
New insights into the therapeutic inhibition of voltage-gated sodium channels.
Channels (Austin, Tex.) - 1 Jan 2000
Ahern Christopher A, Eastwood Amy L, Dougherty Dennis A, Horn Richard
Abstract excerpt
Antiarrhythmics, anticonvulsants and local anesthetics inhibit voltage-gated sodium channels and reduce membrane excitability in neurons and muscle, making them useful in the management of cardiac arrhythmias, epilepsy and pain. These compounds, which are often termed singly in the literature as 'local anesthetics', have at least two inhibitory states: a resting inhibition that develops with intermittent...
Topics
- Anesthetics, Local
- Anti-Arrhythmia Agents
- Binding Sites
- Cations
- Humans
- Hydrogen-Ion Concentration
- Ligands
- Models, Biological
- Models, Chemical
- Molecular Conformation
- Muscle, Skeletal
- Mutation
- Sodium Channels
- Static Electricity