Article

Binding of General Anesthetics to Ion Channels

2018-02-19

Abstract excerpt

<h4>ABSTRACT</h4> The direct-site hypothesis assumes general anesthetics bind ion channels to impact protein equilibrium and function, inducing anesthesia. Despite advancements in the field, a first-principle all-atom demonstration of this structure-function premise misses. We focus on clinically used sevoflurane interaction to anesthetic-sensitive Kv1.2 mammalian channel to resolve if sevoflurane binds the prote...

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Literature Corpus work: b46c7424-8dd6-5e0f-9ebc-b0c12572b44e
DOI: 10.1101/266809

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