Article

tRNA thiolation defects disrupt cellular proteostasis and tissue homeostasis in mammals

2025-10-26

Abstract excerpt

<h4>ABSTRACT</h4> Sulfur modification of tRNA wobble uridines is an evolutionarily conserved mechanism that ensures efficient protein synthesis. In humans, loss of this anticodon modification due to mutations in CTU2 (cytosolic thiouridylase 2) causes DREAM-PL syndrome, a severe congenital disorder often leading to early postnatal death. However, the mechanisms by which loss of tRNA thiolation drives pathology r...

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Literature Corpus work: b749353b-1015-56ce-a364-42453bb964fb
DOI: 10.1101/2025.10.24.684405

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