Article

Human TRMT2A methylates tRNA and contributes to translation fidelity

2022-12-29

Abstract excerpt

Methyl-5-uridine (m5U) is one of the most abundant RNA modifications found in cytosolic tRNA. tRNA methyltransferase 2 homolog A (hTRMT2A) is the dedicated mammalian enzyme of m5U formation at tRNA position 54. However, its RNA binding specificity and functional role in the cell are not well understood. Here we dissected structural and sequence requirements for binding and methylation of its RNA targets. Specifici...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7804f9f1-140e-5f8e-ac23-f188258c6c30
DOI: 10.1101/2022.12.28.522094

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human TRMT2A methylates tRNA and contributes to translation fidelityDOI 10.1101/2022.12.28.522094Read

Human TRMT1 and TRMT1L paralogs ensure the proper modification state, stability, and function of tRNAsSemantic proximity Read

TRMT2B is responsible for both tRNA and rRNA m <sup>5</sup> U-methylation in human mitochondriaSemantic proximity Read

Human TRMT1 and TRMT1L paralogs ensure the proper modification state, stability, and function of tRNAsSemantic proximity Read

Dysregulation of tRNA methylation in cancer: Mechanisms and targeting therapeutic strategiesSemantic proximity Read

tRNA thiolation defects disrupt cellular proteostasis and tissue homeostasis in mammalsSemantic proximity Read

m5U54 tRNA Hypomodification by Lack of TRMT2A Drives the Generation of tRNA-Derived Small RNAsSemantic proximity Read

Base-resolution mapping reveals distinct m <sup>1</sup> A methylome in nuclear- and mitochondrial-encoded transcriptsSemantic proximity Read

The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112Semantic proximity Read

tRNA modifications: greasing the wheels of translation and beyondSemantic proximity Read

The METTL5-TRMT112 <i> N <sup>6</sup> </i> -methyladenosine methyltransferase complex regulates metabolism and development via translationSemantic proximity Read

An intellectual disability‐associated missense variant in TRMT1 impairs tRNA modification and reconstitution of enzymatic activitySemantic proximity Read

m5U54 tRNA Hypomodification by lack of TRMT2A Drives the Generation of tRNA-Derived Small RNAsSemantic proximity Read