Article

The mammalian rapid tRNA decay pathway is critical for N⁷-methylguanosine-hypomodified tRNA degradation under physiological conditions

2025-11-05

Abstract excerpt

<h4>Summary</h4> Chemical modifications of transfer RNAs (tRNAs) are integral to their stability and to translation. Loss of N 7 -methylguanosine (m 7 G) on specific tRNAs reduces their steady-state abundance and impairs translation in mammals, but whether these decreases reflect active degradation under physiological growth conditions is unresolved. Here, using human HCT116 cells, we show that knockdown of the...

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Literature Corpus work: 9402af40-2072-55d8-aac1-6b2e6e028888
DOI: 10.1101/2025.11.05.686800

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