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Human TRMT1 and TRMT1L paralogs ensure the proper modification state, stability, and function of tRNAs

1 Jan 2025

Abstract excerpt

The tRNA methyltransferase 1 (TRMT1) enzyme catalyzes the N2,N2-dimethylguanosine (m2,2G) modification in tRNAs. Intriguingly, vertebrates encode an additional tRNA methyltransferase 1-like (TRMT1L) paralog. Here, we use a comprehensive tRNA sequencing approach to decipher targets of human TRMT1 and TRMT1L. We find that TRMT1 methylates all known tRNAs containing guanosine at position 26, while TRMT1L represents...

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PMID: 39786990
DOI: 10.1016/j.celrep.2024.115092

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