snoRNA-guided tRNA 2’-O-methylation controls codon-biased gene expression and cellular states

Abstract excerpt

<h4>SUMMARY</h4> snoRNAs are a large family of noncoding (nc)RNAs present across eukaryotes and archaea. While a subset of them guide 2’-O- methylation (Nm) and pseudouridylation (Ψ) of rRNAs and snRNAs, targets of most snoRNAs remain unknown. Here we used PARIS2 to map snoRNA targets, revealing an extensive and conserved snoRNA-tRNA interaction network. Using optimized denatured RiboMeth-seq (dRMS), we discovere...

Topics

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• Amyotrophic Lateral Sclerosis
• Intellectual Disability
• Nucleic Acid Conformation
• RNA
• RNA, Mitochondrial
• RNA modifications and cancer
• RNA Processing, Post-Transcriptional
• RNA, Transfer

Identifiers and source

Literature Corpus work

10af89b4-e379-5904-9cb8-703006e59c29

DOI

10.1101/2023.06.22.546166