Article
A stress-induced Tyrosine tRNA depletion response mediates codon-based translational repression and growth suppression
2018-09-13
Abstract excerpt
<h4>SUMMARY</h4> Eukaryotic transfer RNAs can become selectively fragmented upon various stresses, generating tRNA-derived small RNA fragments. Such fragmentation has been reported to impact a small fraction of the tRNA pool and thus presumed to not directly impact translation. We report that oxidative stress can rapidly generate tyrosine tRNA GUA fragments in human cells—causing significant depletion of the pre...
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Identifiers and source
- Literature Corpus work
- cca9b331-06e1-5734-85d5-22028b368152
- DOI
- 10.1101/416727