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The Biology of tRNA t6A Modification and Hypermodifications—Biogenesis and Disease Relevance

29 Mar 2025

Abstract excerpt

• An integrated view and phyletic distribution of the t 6 A family modifications in tRNAs. • tRNA t 6 A family modifications in the ribosome decoding center. • Molecular function and biogenesis of individual t 6 A family modifications. • Consequences of dysregulation of the tRNA t 6 A family modifications in diseases. The structure and function of transfer RNAs (tRNAs) are highly dependent on post-transcriptional...

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PMID: 40155300
DOI: 10.1016/j.jmb.2025.169091

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