TRMT2B is responsible for both tRNA and rRNA m ⁵ U-methylation in human mitochondria

Abstract excerpt

RNA species play host to a plethora of post-transcriptional modifications which together make up the epitranscriptome. 5-methyluridine (m 5 U) is one of the most common modifications made to cellular RNA, where it is found almost ubiquitously in bacterial and eukaryotic cytosolic tRNAs at position 54. Here, we demonstrate that m 5 U54 in human mitochondrial tRNAs is catalysed by the nuclear-encoded enzyme TRMT2B...

Topics

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• ATP Synthase and ATPases Research
• Cancer-related gene regulation
• Peptidase Inhibition and Analysis
• RNA and protein synthesis mechanisms
• RNA modifications and cancer
• Viral-associated cancers and disorders

Identifiers and source

Literature Corpus work

3c2667e7-d5e1-552f-aee4-ae6d806a2e88

DOI

10.1101/797472