Article

Human TRMT1 and TRMT1L paralogs ensure the proper modification state, stability, and function of tRNAs

2024-05-21

Abstract excerpt

<h4>Summary</h4> The tRNA methyltransferase 1 (TRMT1) enzyme catalyzes m2,2G modification in tRNAs. Intriguingly, vertebrates encode an additional tRNA methyltransferase 1-like (TRMT1L) paralog. Here, we use a comprehensive tRNA sequencing approach to decipher targets of human TRMT1 and TRMT1L. We find that TRMT1 methylates all known tRNAs containing guanosine at position 26 while TRMT1L represents the elusive en...

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Literature Corpus work: 717d5b47-bc1c-5ff5-bde3-cd97c8259555
DOI: 10.1101/2024.05.20.594868

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