Article
G34R cancer mutation alters the conformational ensemble and dynamics of the histone H3.3 tails.
Nucleic acids research - 14 Jan 2026
Fuchs Harrison A, Peng Yunhui, Ayyapan Shine, Rosas Ruben, Zhang Houfang, Panchenko Anna R, Musselman Catherine A
Abstract excerpt
Mutations in the histone variant H3.3 have been discovered in pediatric and adult gliomas and osteosarcomas. One of these is G34R in the H3.3 N-terminal tail. While this mutation is known to disrupt epigenomic pathways, the effects on nucleosome structure itself have not been explored. In light of recent studies, which demonstrate that the interaction of the H3 tail with nucleosomal and linker DNA is driven in...
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