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Article

The histone variant H3.3 G34W substitution in giant cell tumor of the bone link chromatin and RNA processing.

Scientific reports - 18 Oct 2017

Lim Jinyeong, Park Joo Hyun, Baude Annika, Yoo Yeongran, Lee Yeon Kyu, Schmidt Christopher R, Park Jong Bae, Fellenberg Jörg, Zustin Josef, Haller Florian, Krücken Irene, Kang Hyun Guy, Park Yoon Jung, Plass Christoph, Lindroth Anders M

Abstract excerpt

While transcription as regulated by histones and their post-translational modifications has been well described, the function of histone variants in this process remains poorly characterized. Potentially important insight into this process pertain to the frequently occurring mutations of H3.3, leading to G34 substitutions in childhood glioblastoma and giant cell tumor of the bone (GCTB). In this study, we have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29044188
DOI: 10.1038/s41598-017-13887-y
PMCID: PMC5647428

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