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Article

Histone H3.3 G34 Mutations Alter Histone H3K36 and H3K27 Methylation In Cis.

Journal of molecular biology - 25 May 2018

Shi Leilei, Shi Jiejun, Shi Xiaobing, Li Wei, Wen Hong

Abstract excerpt

Histone H3 encoding genes, particularly H3F3A and H3F3B, the genes encoding the variant histone H3.3, are mutated at high frequency in pediatric brain and bone malignancies. Compared to the extensive studies on K27M and K36M mutations, little is known about the mechanism of G34 mutations found in pediatric glioblastoma or giant cell tumors of the bone. Here we report that unlike the K27M or K36M that affect...

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Identifiers

PMID: 29689253
DOI: 10.1016/j.jmb.2018.04.014
PMCID: PMC6450091

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