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Article

Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression.

Proceedings of the National Academy of Sciences of the United States of America - 3 Nov 2020

Jain Siddhant U, Khazaei Sima, Marchione Dylan M, Lundgren Stefan M, Wang Xiaoshi, Weinberg Daniel N, Deshmukh Shriya, Juretic Nikoleta, Lu Chao, Allis C David, Garcia Benjamin A, Jabado Nada, Lewis Peter W

Abstract excerpt

A high percentage of pediatric gliomas and bone tumors reportedly harbor missense mutations at glycine 34 in genes encoding histone variant H3.3. We find that these H3.3 G34 mutations directly alter the enhancer chromatin landscape of mesenchymal stem cells by impeding methylation at lysine 36 on histone H3 (H3K36) by SETD2, but not by the NSD1/2 enzymes. The reduction of H3K36 methylation by G34 mutations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33067396
DOI: 10.1073/pnas.2006076117
PMCID: PMC7959516

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