Article
Base-resolution methylomes of gliomas bearing histone H3.3 mutations reveal a G34 mutant-specific signature shared with bone tumors.
Scientific reports - 30 Sept 2020
Sangatsuda Yuhei, Miura Fumihito, Araki Hiromitsu, Mizoguchi Masahiro, Hata Nobuhiro, Kuga Daisuke, Hatae Ryusuke, Akagi Yojiro, Amemiya Takeo, Fujioka Yutaka, Arai Yasuhito, Yoshida Akihiko, Shibata Tatsuhiro, Yoshimoto Koji, Iihara Koji, Ito Takashi
Abstract excerpt
Two recurrent mutations, K27M and G34R/V, in H3F3A, encoding non-canonical histone H3.3, are reported in pediatric and young adult gliomas, whereas G34W mutation is prevalent in bone tumors. In contrast to K27M mutation, it remains elusive how G34 mutations affect the epigenome. Here we performed whole-genome bisulfite sequencing of four G34R-mutated gliomas and the G34V-mutated glioma cell line KNS-42 for...
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