Article
Histone H3 mutations--a special role for H3.3 in tumorigenesis?
Chromosoma - 1 Jun 2015
Kallappagoudar Satish, Yadav Rajesh K, Lowe Brandon R, Partridge Janet F
Abstract excerpt
Brain tumors are the most common solid tumors in children. Pediatric high-grade glioma (HGG) accounts for ∼8-12 % of these brain tumors and is a devastating disease as 70-90 % of patients die within 2 years of diagnosis. The failure to advance therapy for these children over the last 30 years is largely due to limited knowledge of the molecular basis for these tumors and a lack of disease models. Recently,...
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