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<i>CHD8</i> haploinsufficiency alters the developmental trajectories of human excitatory and inhibitory neurons linking autism phenotypes with transient cellular defects

2020-11-26

Abstract excerpt

Chromodomain helicase DNA-binding 8 ( CHD8 ) is one of the most frequently mutated genes causative of autism spectrum disorder (ASD). While its phenotypic spectrum often encompasses macrocephaly and hence implicates cortical abnormalities in this form of ASD, the neurodevelopmental impact of human CHD8 haploinsufficiency remains unexplored. Here we combined human cerebral organoids and single cell transcriptomic...

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Literature Corpus work
b6d03d1d-4c40-58af-8169-bee61fd90329
DOI
10.1101/2020.11.26.399469
Open publication

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<i>CHD8</i> haploinsufficiency alters the developmental trajectories of human excitatory and inhibitory neurons linking autism phenotypes with transient cellular defectsDOI 10.1101/2020.11.26.399469
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