Back to search

Article

Molecular and network disruptions in neurodevelopment uncovered by single cell transcriptomics analysis of <i>CHD8</i> heterozygous cerebral organoids

2023-09-27

Abstract excerpt

About 100 genes have been associated with significantly increased risks of autism spectrum disorders (ASD) with an estimate of ∼1000 genes that may be involved. The new challenge now is to investigate the molecular and cellular functions of these genes during neural and brain development, and then even more challenging, to link the altered molecular and cellular phenotypes to the ASD clinical manifestations. In th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
5310b7e7-d41f-5fac-b25d-db5d471c0aaf
DOI
10.1101/2023.09.27.559752
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Molecular and network disruptions in neurodevelopment uncovered by single cell transcriptomics analysis of <i>CHD8</i> heterozygous cerebral organoidsDOI 10.1101/2023.09.27.559752
Data integration of bulk and single-cell transcriptomics from cerebral organoids and post-mortem brains to identify cell types and cell type specific driver genes in autismSemantic proximity
Human brain organoids reveal accelerated development of cortical neuron classes as a shared feature of autism risk genesSemantic proximity
CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in cerebral organoids derived from iPS cells.Semantic proximity
<i>CHD8</i> haploinsufficiency alters the developmental trajectories of human excitatory and inhibitory neurons linking autism phenotypes with transient cellular defectsSemantic proximity
Identifying cell type specific driver genes in autism-associated copy number loci from cerebral organoidsSemantic proximity
Single-cell brain organoid screening identifies developmental defects in autismSemantic proximity
Benchmarking cerebellar organoids to model autism spectrum disorder and human brain evolutionSemantic proximity
Neurodevelopmental functions of CHD8: new insights and questions.Semantic proximity
Cell type-specific dysregulation of gene expression due to <i>Chd8</i> haploinsufficiency during mouse cortical developmentSemantic proximity
Developmental convergence and divergence in human stem cell models of autism spectrum disorderSemantic proximity
<i>In vivo</i> Perturb-Seq reveals neuronal and glial abnormalities associated with Autism risk genesSemantic proximity
Single cell transcriptome identifies molecular subtype of autism spectrum disorder impacted by de novo loss of function mutation genes regulating glial cellsSemantic proximity
Select a neighboring publication to make it the new centre.