Article
Chd8 haploinsufficiency impairs early brain development and protein homeostasis later in life.
Molecular autism - 5 Oct 2020
Jiménez Jessica A, Ptacek Travis S, Tuttle Alex H, Schmid Ralf S, Moy Sheryl S, Simon Jeremy M, Zylka Mark J
Abstract excerpt
BACKGROUND: Chromodomain helicase DNA-binding protein 8 (Chd8) is a high-confidence risk gene for autism spectrum disorder (ASD). However, how Chd8 haploinsufficiency impairs gene expression in the brain and impacts behavior at different stages of life is unknown. METHODS: We generated a mutant mouse line with an ASD-linked loss-of-function mutation in Chd8 (V986*; stop codon mutation). We examined the behavior...
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