Article
CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in cerebral organoids derived from iPS cells.
Molecular autism - 1 Jan 2017
Wang Ping, Mokhtari Ryan, Pedrosa Erika, Kirschenbaum Michael, Bayrak Can, Zheng Deyou, Lachman Herbert M
Abstract excerpt
BACKGROUND: CHD8 (chromodomain helicase DNA-binding protein 8), which codes for a member of the CHD family of ATP-dependent chromatin-remodeling factors, is one of the most commonly mutated genes in autism spectrum disorders (ASD) identified in exome-sequencing studies. Loss of function mutations in the gene have also been found in schizophrenia (SZ) and intellectual disabilities and influence cancer cell...
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