Article

Autism-associated CHD8 keeps proliferation of human neural progenitors in check by lengthening the G1 phase of the cell cycle

2021-03-04

Abstract excerpt

CHD8 (Chromodomain Helicase DNA Binding Protein 8) is a chromatin remodeler that preferentially regulates expression of genes implicated in early development of the cerebral cortex. De novo mutations (DNMs) in CHD8 are strongly associated with a specific subtype of autism characterized by enlarged foreheads and distinct cranial features. The vast majority of these DNMs are heterozygous loss-of-function mutations...

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Literature Corpus work: 6da0371b-b9b5-5354-a55f-58b6c27fa977
DOI: 10.1101/2021.03.03.433829

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