Article

Human brain organoids reveal accelerated development of cortical neuron classes as a shared feature of autism risk genes

2020-11-12

Abstract excerpt

<h4>ABSTRACT</h4> Genetic risk for autism spectrum disorder (ASD) has been associated with hundreds of genes spanning a wide range of biological functions. The phenotypic alterations in the human brain resulting from mutations in ASD risk genes remain unclear, and the level at which these alterations converge on shared disease pathology is poorly understood. Here, we leveraged reproducible organoid models of the...

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Literature Corpus work: e8dd17e7-8a72-58e7-bb64-bfde5e5bd331
DOI: 10.1101/2020.11.10.376509

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