Article

An adapted stem cell-derived microglia protocol for the study of microgliopathies and other neurological disorders

2023-09-09

Abstract excerpt

<h4>Background</h4> Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is a primary microgliopathy caused by pathogenic variants in the colony-stimulating factor 1 receptor ( CSF1R ) gene. Since CSF1R signaling is crucial for microglia development, survival and function, induced pluripotent stem cell-derived microglia (iMGL) represent an excellent tool in studying microglial defects...

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Literature Corpus work: 9841cc87-05c7-5de1-8a86-351d9f65d674
DOI: 10.1101/2023.09.08.556933

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