Article

The A53T mutation in α-synuclein enhances pro-inflammatory activation in human microglia

2023-08-31

Abstract excerpt

Parkinson’s disease (PD) is characterized by the aggregation of α-synuclein into Lewy bodies and Lewy neurites in the brain. Microglia-driven neuroinflammation may contribute to neuronal death in PD, however the exact role of microglia remains unclear and has been understudied. The A53T mutation in the gene coding for α-synuclein has been linked to early-onset PD, and exposure to A53T-mutant human α-synuclein incr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0cebea8a-6ef8-5ea9-8c7b-e57e04099f55
DOI: 10.1101/2023.08.29.555300

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The A53T mutation in α-synuclein enhances pro-inflammatory activation in human microgliaDOI 10.1101/2023.08.29.555300Read

Microglial PHOX and Mac-1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha-synuclein.Semantic proximity Read

Uptake of alpha-synuclein preformed fibrils is suppressed by inflammation and induces an aberrant phenotype in human microgliaSemantic proximity Read

Glial Innate Immunity Generated by Non-Aggregated Alpha-Synuclein in Mouse: Differences between Wild-type and Parkinson's Disease-Linked MutantsSemantic proximity Read

Functions of Intracellular Alpha-Synuclein in Microglia: Implications for Parkinson’s Disease RiskSemantic proximity Read

Neuroinflammation and Glial Phenotypic Changes in Alpha-SynucleinopathiesSemantic proximity Read

Uptake of alpha-synuclein preformed fibrils is suppressed by inflammation and induces an aberrant phenotype in human microglia.Semantic proximity Read

Model Senescent Microglia Induce Disease Related Changes in α-Synuclein Expression and Activity.Semantic proximity Read

Mutant alpha-synuclein overexpression mediates early proinflammatory activity.Semantic proximity Read

Immunoregulation of Microglia M2 polarization is an unrecognized physiological function of α -SynucleinSemantic proximity Read

Astrocytic expression of Parkinson's disease-related A53T alpha-synuclein causes neurodegeneration in mice.Semantic proximity Read

Long-term polarization of microglia upon α-synuclein overexpression in nonhuman primates.Semantic proximity Read

Microglia integrated neural spheroids enable neuroinflammatory responses and correct network dysfunction induced by alpha-synuclein mutationSemantic proximity Read