Article

Parkinson’s disease microglia induce endogenous α-synuclein pathology in patient-specific midbrain organoids

2025-07-03

Abstract excerpt

The accumulation of misfolded α-synuclein and the loss of dopaminergic neurons are hallmarks of Parkinson’s disease (PD), contributing to the development of synucleinopathies. Although considerable progress has been made in understanding α-synuclein’s role in PD pathology, the precise mechanisms involved remain unclear. Human midbrain organoids (hMOs) have emerged as valuable models for studying PD, yet the lack o...

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Literature Corpus work: 301830a4-27a1-5476-99c3-e43b7d836034
DOI: 10.1101/2025.07.01.662685

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