Article

Structural and Synaptic Dysregulation Drives Network Vulnerability in APOE4 Human Neuronal Networks

2026-05-05

Abstract excerpt

Synaptic failure and associated neuronal network dysfunction are key pathological processes involved in the early stages of Alzheimer’s disease (AD). A better understanding of the specific synaptic pathways and network topologies that drive disease vulnerability is therefore essential for the development of a targeted therapeutic intervention. In the present study, we aimed to determine how defined synaptic pathwa...

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Literature Corpus work: 7f1a109e-37c8-535b-b89b-273def580c14
DOI: 10.64898/2026.05.04.722197

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