Article

Early and lifelong effects of APOE4 on neuronal gene expression networks relevant to Alzheimer’s disease

2022-06-17

Abstract excerpt

Apolipoprotein E4 ( APOE4 ) genotype and aging are critical risk factors for Alzheimer’s disease (AD). Aged APOE4 knock-in (APOE4-KI) mice have phenotypes reflecting features of AD. We conducted a large-scale single nucleus RNA-sequencing study to identify cell-type-specific effects of APOE4 on hippocampal gene expression during aging. APOE4-KI mice showed prominent alterations, relative to APOE3-KI mice, in neur...

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Literature Corpus work: cd6869ef-503f-58f8-a963-23833368395a
DOI: 10.1101/2022.06.16.496371

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