Article

A common mechanism of Sec61 translocon inhibition by small molecules

2022-08-11

Abstract excerpt

The Sec61 complex forms a protein-conducting channel in the endoplasmic reticulum (ER) membrane that is required for secretion of soluble proteins and production of many membrane proteins. Several natural and synthetic small molecules specifically inhibit the Sec61 channel, generating cellular effects that are potentially useful for therapeutic purposes, but their inhibitory mechanisms remain unclear. Here we pres...

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Literature Corpus work: b672a1b5-532a-53f3-b9c3-c972652737bf
DOI: 10.1101/2022.08.11.503542

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