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Structures of multidrug and toxic compound extrusion transporters and their mechanistic implications

21 Oct 2015

Abstract excerpt

Multidrug resistance poses grand challenges to the effective treatment of infectious diseases and cancers. Integral membrane proteins from the multidrug and toxic compound extrusion (MATE) family contribute to multidrug resistance by exporting a wide variety of therapeutic drugs across cell membranes. MATE proteins are conserved from bacteria to humans and can be categorized into the NorM, DinF and eukaryotic...

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PMID: 26488689
DOI: 10.1080/19336950.2015.1106654

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