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Article

Cancer associated mutations in Sec61γ alter the permeability of the ER translocase.

PLoS genetics - 1 Aug 2021

Witham Christopher M, Paxman Aleshanee L, Baklous Lamprini, Steuart Robert F L, Schulz Benjamin L, Mousley Carl J

Abstract excerpt

Translocation of secretory and integral membrane proteins across or into the ER membrane occurs via the Sec61 complex, a heterotrimeric protein complex possessing two essential sub-units, Sec61p/Sec61α and Sss1p/Sec61γ and the non-essential Sbh1p/Sec61β subunit. In addition to forming a protein conducting channel, the Sec61 complex maintains the ER permeability barrier, preventing flow of molecules and ions. Loss...

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Source

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Identifiers

PMID: 34460824
DOI: 10.1371/journal.pgen.1009780
PMCID: PMC8439465

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cancer associated mutations in Sec61γ alter the permeability of the ER translocase.PMID 34460824Read ↗

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