Article
Targeting cell migration and the endoplasmic reticulum stress response with calmodulin antagonists: a clinically tested small molecule phenocopy of SEC62 gene silencing in human tumor cells.
BMC cancer - 5 Dec 2013
Linxweiler Maximilian, Schorr Stefan, Schäuble Nico, Jung Martin, Linxweiler Johannes, Langer Frank, Schäfers Hans-Joachim, Cavalié Adolfo, Zimmermann Richard, Greiner Markus
Abstract excerpt
BACKGROUND: Tumor cells benefit from their ability to avoid apoptosis and invade other tissues. The endoplasmic reticulum (ER) membrane protein Sec62 is a key player in these processes. Sec62 is essential for cell migration and protects tumor cells against thapsigargin-induced ER stress, which are both linked to cytosolic Ca²⁺. SEC62 silencing leads to elevated cytosolic Ca²⁺ and increased ER Ca²⁺ leakage after...
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