Article
Molecular mechanism and structural basis of small-molecule modulation of the gating of acid-sensing ion channel 1.
Communications biology - 9 Feb 2021
Liu Yi, Ma Jichun, DesJarlais Renee L, Hagan Rebecca, Rech Jason, Lin David, Liu Changlu, Miller Robyn, Schoellerman Jeffrey, Luo Jinquan, Letavic Michael, Grasberger Bruce, Maher Michael
Abstract excerpt
Acid-sensing ion channels (ASICs) are proton-gated cation channels critical for neuronal functions. Studies of ASIC1, a major ASIC isoform and proton sensor, have identified acidic pocket, an extracellular region enriched in acidic residues, as a key participant in channel gating. While binding to this region by the venom peptide psalmotoxin modulates channel gating, molecular and structural mechanisms of ASIC...
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