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Article

An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate.

eLife - 1 Jan 2014

Mackinnon Andrew L, Paavilainen Ville O, Sharma Ajay, Hegde Ramanujan S, Taunton Jack

Abstract excerpt

Membrane protein biogenesis requires the coordinated movement of hydrophobic transmembrane domains (TMD) from the cytosolic vestibule of the Sec61 channel into the lipid bilayer. Molecular insight into TMD integration has been hampered by the difficulty of characterizing intermediates during this intrinsically dynamic process. In this study, we show that cotransin, a substrate-selective Sec61 inhibitor, traps...

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Identifiers

PMID: 24497544
DOI: 10.7554/eLife.01483
PMCID: PMC3913039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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