Article

Coibamide A Targets Sec61 to Prevent Biogenesis of Secretory and Membrane Proteins

2019-11-05

Abstract excerpt

Coibamide A (CbA) is a marine natural product with potent antiproliferative activity against human cancer cells and a unique selectivity profile. Despite promising antitumor activity, the mechanism of cytotoxicity and specific cellular target remain unknown. Here, we develop an optimized synthetic CbA photoaffinity probe (photo-CbA) and use it to demonstrate that CbA directly targets the Sec61α subunit of the trim...

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Identifiers and source

Literature Corpus work: 917379ba-482d-54bd-95ba-3657e177998c
DOI: 10.26434/chemrxiv.10092182.v1

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