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Article

Translocation of proteins through the Sec61 and SecYEG channels.

Current opinion in cell biology - 1 Aug 2009

Mandon Elisabet C, Trueman Steven F, Gilmore Reid

Abstract excerpt

The Sec61 and SecYEG translocation channels mediate the selective transport of proteins across the endoplasmic reticulum and bacterial inner membrane, respectively. These channels are also responsible for the integration of membrane proteins. To accomplish these two critical events in protein expression, the transport channels undergo conformational changes to permit the export of lumenal domains and the...

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Source

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Identifiers

PMID: 19450960
DOI: 10.1016/j.ceb.2009.04.010
PMCID: PMC2916700

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Translocation of proteins through the Sec61 and SecYEG channels.PMID 19450960Read ↗

The SecY translocation complex: convergence of genetics and structure.Semantic proximity Read ↗

A gating motif in the translocation channel sets the hydrophobicity threshold for signal sequence function.Semantic proximity Read ↗

Translocation channel gating kinetics balances protein translocation efficiency with signal sequence recognition fidelity.Semantic proximity Read ↗

Dynamic action of the Sec machinery during initiation, protein translocation and termination.Semantic proximity Read ↗

Unlocking the Bacterial SecY Translocon.Semantic proximity Read ↗

The bacterial translocon SecYEG opens upon ribosome binding.Semantic proximity Read ↗

Nanodiscs unravel the interaction between the SecYEG channel and its cytosolic partner SecA.Semantic proximity Read ↗

SecY and SecA interact to allow SecA insertion and protein translocation across the Escherichia coli plasma membrane.Semantic proximity Read ↗

A SecE mutation that modulates SecY-SecE translocase assembly, identified as a specific suppressor of SecY defects.Semantic proximity Read ↗

Sss1p is required to complete protein translocon activation.Semantic proximity Read ↗

Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranes.Semantic proximity Read ↗

Dynamics of SecY translocons with translocation-defective mutations.Semantic proximity Read ↗

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