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Article

Structures of human pannexin 1 reveal ion pathways and mechanism of gating.

Nature - 1 Aug 2020

Ruan Zheng, Orozco Ian J, Du Juan, Lü Wei

Abstract excerpt

Pannexin 1 (PANX1) is an ATP-permeable channel with critical roles in a variety of physiological functions such as blood pressure regulation1, apoptotic cell clearance2 and human oocyte development3. Here we present several structures of human PANX1 in a heptameric assembly at resolutions of up to 2.8 angström, including an apo state, a caspase-7-cleaved state and a carbenoxolone-bound state. We reveal a gating...

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Identifiers

PMID: 32494015
DOI: 10.1038/s41586-020-2357-y
PMCID: PMC7814660

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