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Article

Structure of the Inhibited State of the Sec Translocon.

Molecular cell - 6 Aug 2020

Gérard Samuel F, Hall Belinda S, Zaki Afroditi M, Corfield Katherine A, Mayerhofer Peter U, Costa Catia, Whelligan Daniel K, Biggin Philip C, Simmonds Rachel E, Higgins Matthew K

Abstract excerpt

Protein secretion in eukaryotes and prokaryotes involves a universally conserved protein translocation channel formed by the Sec61 complex. Unrelated small-molecule natural products and synthetic compounds inhibit Sec61 with differential effects for different substrates or for Sec61 from different organisms, making this a promising target for therapeutic intervention. To understand the mode of inhibition and...

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Identifiers

PMID: 32692975
DOI: 10.1016/j.molcel.2020.06.013
PMCID: PMC7427319

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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