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Article

Decatransin, a new natural product inhibiting protein translocation at the Sec61/SecYEG translocon.

Journal of cell science - 15 Mar 2015

Junne Tina, Wong Joanne, Studer Christian, Aust Thomas, Bauer Benedikt W, Beibel Martin, Bhullar Bhupinder, Bruccoleri Robert, Eichenberger Jürg, Estoppey David, Hartmann Nicole, Knapp Britta, Krastel Philipp, Melin Nicolas, Oakeley Edward J, Oberer Lukas, Riedl Ralph, Roma Guglielmo, Schuierer Sven, Petersen Frank, Tallarico John A, Rapoport Tom A, Spiess Martin, Hoepfner Dominic

Abstract excerpt

A new cyclic decadepsipeptide was isolated from Chaetosphaeria tulasneorum with potent bioactivity on mammalian and yeast cells. Chemogenomic profiling in S. cerevisiae indicated that the Sec61 translocon complex, the machinery for protein translocation and membrane insertion at the endoplasmic r...

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Identifiers

PMID: 25616894
DOI: 10.1242/jcs.165746
PMCID: PMC4359925

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25616894-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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