Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Signal peptide mimicry primes Sec61 for client-selective inhibition

11 May 2023

Abstract excerpt

Preventing the biogenesis of disease-relevant proteins is an attractive therapeutic strategy, but attempts to target essential protein biogenesis factors have been hampered by excessive toxicity. Here we describe KZR-8445, a cyclic depsipeptide that targets the Sec61 translocon and selectively disrupts secretory and membrane protein biogenesis in a signal peptide-dependent manner. KZR-8445 potently inhibits the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chemical Synthesis and Analysis
Share to Click Chemistry and Applications
Share to Monoclonal and Polyclonal Antibodies Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37169961
DOI: 10.1038/s41589-023-01326-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Signal peptide mimicry primes Sec61 for client-selective inhibitionPMID 37169961Read ↗

Structure of the Inhibited State of the Sec Translocon.Semantic proximity Read ↗

A common mechanism of Sec61 translocon inhibition by small moleculesSemantic proximity Read ↗

Intrinsic flexibility of Type VII secretion central pore is required for substrate translocationSemantic proximity Read ↗

<i>De novo</i> macrocyclic peptides for inhibiting, stabilising and probing the function of the Retromer endosomal trafficking complexSemantic proximity Read ↗

HOPS-dependent endosomal fusion required for efficient cytosolic delivery of therapeutic peptides and small proteinsSemantic proximity Read ↗

Mechanistic insights into the inhibition of Sec61-dependent co- and post-translational translocation by mycolactoneSemantic proximity Read ↗

Lipoproteins modulate the uptake and biological function of cationic cell-penetrating peptides across the animal lineage.Semantic proximity Read ↗

Aberrant phase separation is a common killing strategy of positively charged peptides in biology and human diseaseSemantic proximity Read ↗

An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate.Semantic proximity Read ↗

The bacterial toxin ExoU requires a host trafficking chaperone for transportation and to induce necrosisSemantic proximity Read ↗

Mechanism of loading and translocation of type VI secretion system effector Tse6.Semantic proximity Read ↗

A cure for traffic jams: small molecule chaperones in the endoplasmic reticulum.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.