Article

Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulation

2020-01-18

Abstract excerpt

<h4>Background</h4> The three-dimensional genome organization is critical for gene regulation and can malfunction in diseases like cancer. As a key regulator of genome organization, CCCTC-binding factor (CTCF) has been characterized as a DNA-binding protein with important functions in maintaining the topological structure of chromatin and inducing DNA looping. Among the prolific binding sites in the genome, sever...

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Literature Corpus work: b5fcb79e-1274-507e-9101-cc272e3ade5d
DOI: 10.1101/2020.01.17.910687

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